10 Best Enzymatic Cleaners For Dog Urine of 2026

Last updated on 05/11/2026
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1
9.8
Exceptional
Save 20%
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
ACTIVE

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

20% Off
Why we love it
  • Completely eliminates odors and stains.
  • Powerful enzymatic cleaning formula.
  • Safe for pets and children.
Main Highlights
  • Completely Eliminate Odors & Stains: Our ready-to-use Advanced Pet Odor Eliminator Sprays target the source of animal messes, Lifting Stains and Removing Smells, leaving behind only a Pleasant Citrus Oil Scent! Compare to other products that only mask the problem instead of actually deodorizing
  • Bio Enzymatic Odor Destroyer: ACTIVE Pet Stain and Odor Remover Formula is specially made with Enzymes and Natural Probiotics that Remove Smell from Puppy Accidents, Cat Urine, and all odour from Pee, Poop, Vomit, Litter and more
  • Professional Stain Removal: ACTIVE Enzyme Cleaners will easily get rid of mess and set-in stains in Carpets, Fabric, Floor. Our powerful Stain Eliminating Solution creates a Deep Cleaning Lather with every Spray for full Stain Treatment
  • Designed for Home Surfaces: Universal Indoor Pet Clean-up Spray for couch stains, Wood Floors, Rug, Furniture, Mattress, Dog bed, Kennel- wherever your pet goes! Get any hard to clean accident in the house with ACTIVE deodorizers and animal stain removers
  • Proudly Made in USA: ACTIVE Pet Odor Neutralizer Spray is made entirely in the United States with just the best components and ingredients. Our Formula is gentle yet Effective, and Safe to use around Pets and Kids
  • Product Usage Instructions: Spray directly onto the pet stain and surrounding area to ensure full and even coverage. Allow the solution to soak up to one hour so it can get deep into the carpet, rug, or upholstery fibers to break down stains and odor-causing residues. After soaking, blot the area with a clean cloth to lift grime & debris. For tough stains, apply more cleaner, lightly agitate the area with a soft brush or cloth, and reapply as needed. Finish by wiping the area dry or extract remaining moisture with carpet cleaner for best results
9.8
Exceptional
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🛡️Trusted by 100M+ UsersWhy?
Best Value
2
9.6
Superb
Save 10%
ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz
ANGRY ORANGE

ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz

10% Off
Why we love it
  • Destroys tough pet odors effectively.
  • Cleans stains on various surfaces.
  • Natural orange oil leaves freshness.
Main Highlights
  • DESTROYS TOUGH PET ODORS – Tackles strong smells from dog and cat urine, feces, vomit, and more. Works fast to eliminate lingering odors at the source.
  • CLEANS STAINS ON FLOORS & MORE – Designed for use on hard and sealed surfaces where pet messes happen most. Works fast to eliminate lingering odors at the source.
  • SCENT POWERED BY NATURAL ORANGE OIL – Has the power of real orange oil, leaving a pleasant citrus scent behind without harsh smells.
  • SAFE FOR HOMES WITH PETS WHEN USED AS DIRECTED – No added parabens, sulfates, or phthalates. No chemical stink. Powerful cleaning without the harsh stink.
  • MADE IN THE USA – Proudly formulated and manufactured in the USA for pet owners who care about quality and safety.
9.6
Superb
Save 10%
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3
9.5
Superb
Eco Strong Outdoor Odor Eliminator | Outside Dog Urine Enzyme Cleaner – Powerful Pet, Cat, Animal Scent Deodorizer | Professional Strength for Yard, Turf, Kennels, Patios, Decks (Gallon with Sprayer)
Eco Strong

Eco Strong Outdoor Odor Eliminator | Outside Dog Urine Enzyme Cleaner – Powerful Pet, Cat, Animal Scent Deodorizer | Professional Strength for Yard, Turf, Kennels, Patios, Decks (Gallon with Sprayer)

Why we love it
  • Powerful odor elimination solution.
  • Safe for pets and children.
  • Versatile for various outdoor surfaces.
Main Highlights
  • Powerful Natural Odor Eraser: This Chemical-free formula is a pet poop & pee smell destroyer. Spray it on any outdoor surface, and odors will quickly disappear. The only thing left behind will be a fresh eucalyptus scent.
  • Multi-Surface Safe: Effective on virtually all outdoor surfaces; turf, grass, rock, dirt, fences, furniture, concrete, wooden decks, and more.
  • Paw & Barefoot Safe: This professional strength bio-enzymatic solution erases offensive odors without leaving residue behind. This product does not contain any harmful chemicals.
  • New Rugged Multi-Use Sprayer: We are happy to introduce our more durable higher quality sprayer.
  • Multi-Use Formula: Erase pet and animal urine, stool, vomit, skunk, or even garbage odors from your outdoor spaces.
9.5
Superb
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4
9.5
Superb
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Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon
Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

20% OffLimited time deal
Why we love it
  • Certified safe for carpets.
  • Eliminates tough stains effectively.
  • Suitable for all surfaces.
Main Highlights
  • Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
  • Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it right
9.5
Superb
Save 20%
Limited time deal
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5
9.4
Superb
Save 22%
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces
Biokleen

Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

22% Off
Why we love it
  • Effective on tough stains.
  • Preferred by professionals nationwide.
  • Eco-friendly, plant-based ingredients.
Main Highlights
  • STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
  • PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
  • BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
  • PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
  • MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts
9.4
Superb
Save 22%
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6
9.3
Superb
Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon
Kinzua Environmental

Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Original Scent, 1 Gallon

Why we love it
  • Powerful formula eliminates tough odors.
  • Safe for pets and children.
  • Versatile for all cleaning tasks.
Main Highlights
  • Powerful & Effective Cleaner: Each gallon of Urine B-Gone is loaded with 200 billion microbe colonies, working tirelessly to liquefy, digest, and eliminate urine and poop; This high-strength formula ensures your home stays fresh and free from unpleasant odors
  • Deep Penetration, Lasting Results: Urine B-Gone doesn’t just mask odors; it attacks them at the source; This powerful enzyme cleaner penetrates deep into any carpet and upholstery, removing stains and neutralizing smells even from padding and the floor beneath; Its versatile formula makes it suitable for all cleaning tasks, ensuring every surface is left fresh and spotless
  • Safe for Your Home: Our natural enzyme formula is safe to use around pets and children when used as directed; It’s designed to be gentle yet highly effective, providing peace of mind while maintaining a clean and odor-free environment; Enjoy the fresh scent of our urine cleaner
  • Versatile Cleaning Solution: Beyond pet stains, Urine B-Gone is ideal for a variety of applications; Use it in your laundry to pre-spray soiled areas or even in drains, urinals, and toilets; This all-in-one cleaner & odor remover makes tackling tough stains and odors simple and efficient
  • About Us: At Kinzua Environmental, we specialize in premium cleaning solutions that are safe and professional strength for both commercial and household applications
9.3
Superb
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7
9.2
Superb
Save 20%
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

20% OffLimited time deal
Why we love it
  • Certified safe for kids and pets.
  • Eliminates tough stains and odors.
  • Works on all surfaces everywhere.
Main Highlights
  • Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
  • Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx
9.2
Superb
Save 20%
Limited time deal
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8
9.1
Superb
Save 20%
Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training
Rocco & Roxie Supply Co.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

20% OffLimited time deal
Why we love it
  • Eliminates tough stains effortlessly.
  • Safe for pets and children.
  • Fresh lemon scent, no residue.
Main Highlights
  • Eliminates Stains, Odors, & Residue: If it’s gross, it’s gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
  • Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
  • Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
  • Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right
9.1
Superb
Save 20%
Limited time deal
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9
9.1
Superb
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Why we love it
  • Versatile cleaning for multiple applications.
  • Long-lasting probiotics for effective cleaning.
  • Eliminates odors at the source.
Main Highlights
  • THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
  • ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
  • NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
  • ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
  • MADE IN THE USA - 1 Gallon Bottle
9.1
Superb
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10
9.0
Superb
Save 16%
Nature’s Miracle Stain & Odor Remover, Tough on Dog Urine, Feces, Vomit, Drool and Other Organic Stains and Odors, 170 fl oz Refill
Nature's Miracle

Nature’s Miracle Stain & Odor Remover, Tough on Dog Urine, Feces, Vomit, Drool and Other Organic Stains and Odors, 170 fl oz Refill

16% Off
Why we love it
  • Tough on tough stains.
  • Multi-surface safe use.
  • Pet-friendly and effective.
Main Highlights
  • TOUGH ON STAINS AND ODORS: This stain and odor remover is tough on dog urine, feces, vomit, drool and other organic stains and odors.
  • MULTI-SURFACE USE: When used and stored as directed, this product is safe for use on carpets, hard floors, furniture, fabrics and more.
  • SAFE FOR PETS AND HOME: We’ve been loved by pet parents for over 35 years, so we know the importance of having an effective stain and odor remover that, when used and stored as directed, is safe to use around pets.
  • CITRUS SCENT: In addition to removing stains and odors, this product freshens with a light citrus scent.
  • GUARANTEED TO WORK OR YOUR MONEY BACK**: We’re sure you’re going to be very happy and mess free. But, if you are not satisfied with this product for any reason, we will make it right. **For terms of guarantee, see back of product.
9.0
Superb
Save 16%
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Related Deals You Might Like for Enzymatic Cleaners For Dog Urine

📊We scanned 1679 products
🔍
We reviewed the most relevant Enzymatic Cleaners For Dog Urine offers across Amazon and leading retailers, covering major brands and models. Our shortlist features trusted names like ACTIVE, ANGRY ORANGE, Eco Strong, Rocco & Roxie Supply Co., Biokleen, Kinzua Environmental, Bioda, Nature's Miracle, known for dependable quality and smart design.
⭐
To determine today's best Enzymatic Cleaners For Dog Urine, we analyzed 8396 real customer and expert reviews, focusing on satisfaction, real-world performance and long-term reliability. We also weigh each review's relevance, authenticity and freshness for a fair comparison.

Here's what we found:

🏆 #1
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

Our overall winner is Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil by ACTIVE. It stands out for the right balance of quality, performance and value.

✨ What sets it apart:
✓Completely eliminates odors and stains.
✓Powerful enzymatic cleaning formula.
✓Safe for pets and children.
💎 Best Value
ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz

The best value for most shoppers is ANGRY ORANGE Pet Odor Eliminator for Dog and Cat Urine, Carpet Stains, and Strong Smells – Citrus Cleaner with Natural Orange Oil – 24 oz by ANGRY ORANGE, with consistently high satisfaction across expert and customer reviews.

💰 Best Deal
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

The strongest deal right now for Enzymatic Cleaners For Dog Urine is Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces at Biokleen, currently at 22% off.

🔄Our Enzymatic Cleaners For Dog Urine ranking is updated regularly to reflect new releases and price changes-check back for the latest picks and deals.