10 Best Enzymatic Cleaner For Cat Urine of 2026

Last updated on 04/02/2026
Advertising disclosure
Best Choice
1
9.7
Exceptional
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon
Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Why we love it
  • Certified safe for carpets.
  • Eliminates tough stains effectively.
  • Suitable for all surfaces.
Main Highlights
  • Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
  • Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it right
9.7
Exceptional
Amazon Logo
🛡️Trusted by 100M+ UsersWhy?
Best Value
2
9.6
Superb
Save 18%
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
ACTIVE

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

18% Off
Why we love it
  • Completely eliminates odors and stains.
  • Powerful enzymatic cleaning formula.
  • Safe for pets and children.
Main Highlights
  • Completely Eliminate Odors & Stains: Our ready-to-use Advanced Pet Odor Eliminator Sprays target the source of animal messes, Lifting Stains and Removing Smells, leaving behind only a Pleasant Citrus Oil Scent! Compare to other products that only mask the problem instead of actually deodorizing
  • Bio Enzymatic Odor Destroyer: ACTIVE Pet Stain and Odor Remover Formula is specially made with Enzymes and Natural Probiotics that Remove Smell from Puppy Accidents, Cat Urine, and all odour from Pee, Poop, Vomit, Litter and more
  • Professional Stain Removal: ACTIVE Enzyme Cleaners will easily get rid of mess and set-in stains in Carpets, Fabric, Floor. Our powerful Stain Eliminating Solution creates a Deep Cleaning Lather with every Spray for full Stain Treatment
  • Designed for Home Surfaces: Universal Indoor Pet Clean-up Spray for couch stains, Wood Floors, Rug, Furniture, Mattress, Dog bed, Kennel- wherever your pet goes! Get any hard to clean accident in the house with ACTIVE deodorizers and animal stain removers
  • Proudly Made in USA: ACTIVE Pet Odor Neutralizer Spray is made entirely in the United States with just the best components and ingredients. Our Formula is gentle yet Effective, and Safe to use around Pets and Kids
  • Product Usage Instructions: Spray directly onto the pet stain and surrounding area to ensure full and even coverage. Allow the solution to soak up to one hour so it can get deep into the carpet, rug, or upholstery fibers to break down stains and odor-causing residues. After soaking, blot the area with a clean cloth to lift grime & debris. For tough stains, apply more cleaner, lightly agitate the area with a soft brush or cloth, and reapply as needed. Finish by wiping the area dry or extract remaining moisture with carpet cleaner for best results
9.6
Superb
Save 18%
Amazon Logo
3
9.4
Superb
Save 22%
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces
Biokleen

Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

22% Off
Why we love it
  • Effective on tough stains.
  • Preferred by professionals nationwide.
  • Eco-friendly, plant-based ingredients.
Main Highlights
  • STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
  • PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
  • BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
  • PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
  • MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts
9.4
Superb
Save 22%
Amazon Logo
4
9.4
Superb
Nature’s Miracle Urine Destroyer Plus for Cats, Enzymatic Formula Tough on Strong Cat Urine And The Yellow Sticky Residue, 1 Gal
Nature's Miracle

Nature’s Miracle Urine Destroyer Plus for Cats, Enzymatic Formula Tough on Strong Cat Urine And The Yellow Sticky Residue, 1 Gal

Why we love it
  • Breaks down stains instantly.
  • Easy refill with large bottle.
  • Safe for pets and home.
Main Highlights
  • FOR CAT URINE MESSES: Begins to break down and remove stains immediately on contact.
  • GREAT FOR REFILLS: The 128-ounce bottle is easy to pour and great for refilling smaller bottles.
  • ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
  • TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
  • SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.
9.4
Superb
Amazon Logo
5
9.3
Superb
AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack
AmazonCommercial

AmazonCommercial Multi-Purpose Enzyme Cleaner, Stain & Odor Remover, Pet Stain Remover, 1-Gallon, 1-Pack

Why we love it
  • Powerful stain removal solution.
  • Versatile for multiple surfaces.
  • Perfect for commercial use.
Main Highlights
  • 1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
  • Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
  • Ideal for commercial properties, retail, and hospitality
  • Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more
9.3
Superb
Amazon Logo
6
9.3
Superb
Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon
KINZUA ENVIRONMENTAL

Urine B-Gone, Professional Enzyme Odor Eliminator & Pet Stain Remover, Human, Cat & Dog Urine Cleaner, Effective on Laundry, Carpets & More, Lavender Scent, 1 Gallon

Why we love it
  • Powerful enzymes attack tough stains.
  • Safe for kids and pets.
  • Leaves a soothing lavender scent.
Main Highlights
  • Powerful & Effective Cleaner: Each gallon of Urine B-Gone is loaded with 200 billion microbe colonies, working tirelessly to liquefy, digest, and completely eliminate urine and poop; This high-strength formula ensures your home stays fresh and free from unpleasant odors while leaving behind a soothing lavender fragrance
  • Deep Penetration, Lasting Results: Urine B-Gone doesn’t just mask odors; it attacks them at the source; This powerful enzyme cleaner penetrates deep into any carpet and upholstery, removing stains and neutralizing smells even from padding and the floor beneath; Its versatile formula makes it suitable for all cleaning tasks, ensuring every surface is left fresh and spotless
  • Safe for Your Home: Our natural enzyme formula is safe to use around pets and children when used as directed; It’s designed to be gentle yet highly effective, providing peace of mind while maintaining a clean and odor-free environment; Enjoy the fresh scent of our urine cleaner
  • Versatile Cleaning Solution: Beyond pet stains, Urine B-Gone is ideal for a variety of applications; Use it in your laundry to pre-spray soiled areas or even in drains, urinals, and toilets; This all-in-one cleaner & odor remover makes tackling tough stains and odors simple and efficient
  • About Us: At Kinzua Environmental, we specialize in premium cleaning solutions that are safe and professional strength for both commercial and household applications
9.3
Superb
Amazon Logo
7
9.1
Superb
Nature’s Miracle Set-In Stain Destroyer, 1 Gallon, For Cat Messes, Oxy Formula With Orange Scent
Nature's Miracle

Nature’s Miracle Set-In Stain Destroyer, 1 Gallon, For Cat Messes, Oxy Formula With Orange Scent

Why we love it
  • Destroys even the toughest stains.
  • Light orange scent freshens home.
  • Safe for pets and environment.
Main Highlights
  • DESTROYS SET-IN STAINS: Use for even deep-set stains and severe, old or stubborn odors.
  • LIGHT ORANGE SCENT: Cat odor control formula gets your home smelling clean again.
  • OXY FORMULA: Oxygen concentrate penetrates, separates and lifts embedded stains and odors.
  • TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
  • SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and home.
9.1
Superb
Amazon Logo
8
9.0
Superb
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Why we love it
  • Certified safe for kids and pets.
  • Eliminates tough stains and odors.
  • Works on all surfaces everywhere.
Main Highlights
  • Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
  • Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx
9.0
Superb
Amazon Logo
9
9.0
Superb
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Why we love it
  • Versatile cleaning for multiple applications.
  • Long-lasting probiotics for effective cleaning.
  • Eliminates odors at the source.
Main Highlights
  • THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
  • ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
  • NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
  • ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
  • MADE IN THE USA - 1 Gallon Bottle
9.0
Superb
Amazon Logo
10
8.8
Excellent
Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training
Rocco & Roxie Supply Co.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Why we love it
  • Eliminates tough stains effortlessly.
  • Safe for pets and children.
  • Fresh lemon scent, no residue.
Main Highlights
  • Eliminates Stains, Odors, & Residue: If it’s gross, it’s gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
  • Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
  • Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
  • Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right
8.8
Excellent
Amazon Logo

Related Deals You Might Like for Enzymatic Cleaner For Cat Urine

📊We scanned 422 products
🔍
We reviewed the most relevant Enzymatic Cleaner For Cat Urine offers across Amazon and leading retailers, covering major brands and models. Our shortlist features trusted names like Rocco & Roxie Supply Co., ACTIVE, Biokleen, Nature's Miracle, AmazonCommercial, KINZUA ENVIRONMENTAL, Bioda, known for dependable quality and smart design.
⭐
To determine today's best Enzymatic Cleaner For Cat Urine, we analyzed 2111 real customer and expert reviews, focusing on satisfaction, real-world performance and long-term reliability. We also weigh each review's relevance, authenticity and freshness for a fair comparison.

Here's what we found:

🏆 #1
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon

Our overall winner is Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray, 1-Gallon by Rocco & Roxie Supply Co.. It stands out for the right balance of quality, performance and value.

✨ What sets it apart:
✓Certified safe for carpets.
✓Eliminates tough stains effectively.
✓Suitable for all surfaces.
💎 Best Value
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

The best value for most shoppers is Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil by ACTIVE, with consistently high satisfaction across expert and customer reviews.

💰 Best Deal
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

The strongest deal right now for Enzymatic Cleaner For Cat Urine is Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces at Biokleen, currently at 22% off.

🔄Our Enzymatic Cleaner For Cat Urine ranking is updated regularly to reflect new releases and price changes—check back for the latest picks and deals.