10 Best Cat Urine Enzyme Cleaner of 2026

Last updated on 04/04/2026
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Best Choice
1
9.8
Exceptional
Save 18%
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil
ACTIVE

Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

18% Off
Why we love it
  • Completely eliminates odors and stains.
  • Powerful enzymatic cleaning formula.
  • Safe for pets and children.
Main Highlights
  • Completely Eliminate Odors & Stains: Our ready-to-use Advanced Pet Odor Eliminator Sprays target the source of animal messes, Lifting Stains and Removing Smells, leaving behind only a Pleasant Citrus Oil Scent! Compare to other products that only mask the problem instead of actually deodorizing
  • Bio Enzymatic Odor Destroyer: ACTIVE Pet Stain and Odor Remover Formula is specially made with Enzymes and Natural Probiotics that Remove Smell from Puppy Accidents, Cat Urine, and all odour from Pee, Poop, Vomit, Litter and more
  • Professional Stain Removal: ACTIVE Enzyme Cleaners will easily get rid of mess and set-in stains in Carpets, Fabric, Floor. Our powerful Stain Eliminating Solution creates a Deep Cleaning Lather with every Spray for full Stain Treatment
  • Designed for Home Surfaces: Universal Indoor Pet Clean-up Spray for couch stains, Wood Floors, Rug, Furniture, Mattress, Dog bed, Kennel- wherever your pet goes! Get any hard to clean accident in the house with ACTIVE deodorizers and animal stain removers
  • Proudly Made in USA: ACTIVE Pet Odor Neutralizer Spray is made entirely in the United States with just the best components and ingredients. Our Formula is gentle yet Effective, and Safe to use around Pets and Kids
  • Product Usage Instructions: Spray directly onto the pet stain and surrounding area to ensure full and even coverage. Allow the solution to soak up to one hour so it can get deep into the carpet, rug, or upholstery fibers to break down stains and odor-causing residues. After soaking, blot the area with a clean cloth to lift grime & debris. For tough stains, apply more cleaner, lightly agitate the area with a soft brush or cloth, and reapply as needed. Finish by wiping the area dry or extract remaining moisture with carpet cleaner for best results
9.8
Exceptional
Save 18%
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🛡️Trusted by 100M+ UsersWhy?
Best Value
2
9.6
Superb
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon
Bioda

Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

Why we love it
  • Versatile cleaning for multiple applications.
  • Long-lasting probiotics for effective cleaning.
  • Eliminates odors at the source.
Main Highlights
  • THE POWER OF ONE: This versatile product is the only probiotic cleaner you need, providing powerful cleaning performance in a wide variety of applications. Multipurpose use: Maintain clean drain lines and septic tanks to prevent clogs and potential buildup. Clean and deodorize trash bins, stains and odors on floors, carpets, bathroom surfaces, kitchen surfaces, and more.
  • ACTIVE UP TO 21 DAYS: Our specialized probiotics continue to clean soils in cracks, grout and tough to reach places. Simply spray & let the probiotics do the dirty work!
  • NATURALLY, SUPERIOR RESULTS: A special blend of enzyme-producing probiotics break down complex proteins, fats, oils, greases, and other organic waste. The enzymes digest the soils until they have been eliminated, providing a long-lasting, continuous clean without leaving a residue or harmful by-products behind.
  • ELIMINATE ODOR: Provide total odor control by eliminating the actual source of even the most pungent organic malodors naturally, including rotting food, urine, feces, vomit, and trash. Plus, the fresh lemon and sage fragrance leaves behind a light, pleasant scent that rejuvenates the air of any environment.
  • MADE IN THE USA - 1 Gallon Bottle
9.6
Superb
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3
9.6
Superb
Nature’s Miracle Set-In Stain Destroyer, 1 Gallon, For Cat Messes, Oxy Formula With Orange Scent
Nature's Miracle

Nature’s Miracle Set-In Stain Destroyer, 1 Gallon, For Cat Messes, Oxy Formula With Orange Scent

Why we love it
  • Destroys even the toughest stains.
  • Light orange scent freshens home.
  • Safe for pets and environment.
Main Highlights
  • DESTROYS SET-IN STAINS: Use for even deep-set stains and severe, old or stubborn odors.
  • LIGHT ORANGE SCENT: Cat odor control formula gets your home smelling clean again.
  • OXY FORMULA: Oxygen concentrate penetrates, separates and lifts embedded stains and odors.
  • TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
  • SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and home.
9.6
Superb
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4
9.6
Superb
Save 22%
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces
Biokleen

Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

22% Off
Why we love it
  • Effective on tough stains.
  • Preferred by professionals nationwide.
  • Eco-friendly, plant-based ingredients.
Main Highlights
  • STAIN AND ODOR REMOVER: Bac-Out safely works wonders on pet accidents, wine spills on carpets and couches, cloth diapers and pails, laundry, disposals, garbage cans and much more.
  • PREFERRED BY PROFFESSIONALS: Bac-Out is the preferred choice of commercial carpet cleaners nationwide.
  • BIO ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
  • PLANT BASED CLEANER: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
  • MADE IN THE USA: We use biodegradable ingredients, never test on animals, and are manufactured in the USA with US and imported parts
9.6
Superb
Save 22%
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5
9.5
Superb
Nature’s Miracle Urine Destroyer Plus for Cats, Enzymatic Formula Tough on Strong Cat Urine And The Yellow Sticky Residue, 1 Gal
Nature's Miracle

Nature’s Miracle Urine Destroyer Plus for Cats, Enzymatic Formula Tough on Strong Cat Urine And The Yellow Sticky Residue, 1 Gal

Why we love it
  • Breaks down stains instantly.
  • Easy refill with large bottle.
  • Safe for pets and home.
Main Highlights
  • FOR CAT URINE MESSES: Begins to break down and remove stains immediately on contact.
  • GREAT FOR REFILLS: The 128-ounce bottle is easy to pour and great for refilling smaller bottles.
  • ENZYMATIC FORMULA: Continues working as long as any bio-based mess is still present.
  • TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works!
  • SAFE FOR PETS AND HOME: When used and stored as directed, this formula can be used around your pets and in your home.
9.5
Superb
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6
9.3
Superb
Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training
Rocco & Roxie Supply Co.

Rocco & Roxie Extreme Stain & Odor Eliminator for Strong Odor, Pet Urine Enzyme Cleaner Destroyer, Stain Remover, Dog Poop and Cat Pee, Enzymatic Carpet Cleaner Spray for Home, Puppy Potty Training

Why we love it
  • Eliminates tough stains effortlessly.
  • Safe for pets and children.
  • Fresh lemon scent, no residue.
Main Highlights
  • Eliminates Stains, Odors, & Residue: If it’s gross, it’s gone; from blowouts, urine, vomit, and other organic spills; Rocco & Roxie stain & odor eliminator has a subtle Meyer lemon scent that quickly dissipates, leaving your space feeling fresher
  • Every Surface, Every Time: Our fast-acting carpet stain remover spray formula works great on floors, furniture, clothing, pet bedding, litter boxes, travel crates, hamster cages, cars, campers, and anywhere else major accidents happen
  • Minerals & Enzymes: The key is getting to the problem deep-down, so we added a mineral-based odor neutralizer to our bio-enzymatic formula; upon contact with tough stains & odors, this pet enzyme cleaner feasts on ammonia crystals and organic matter
  • Gentle & Safe Carpet Spray: Safe to use around pets and children, when used as directed; chlorine-free, color-safe with no hazardous propellants; Certified Safe for all carpets with the Seal of Approval by the trusted Carpet and Rug Institute (CRI)
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this pet odor eliminator and stain remover, contact us; we are determined to make it right
9.3
Superb
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7
9.2
Superb
Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)
Black Diamond Stoneworks

Commercial Multi-Purpose Enzyme Cleaner & Odor Eliminator | Pet & Human Urine, Stains & Odors | Carpet, Laundry, Bathroom, Drain & Trash Deodorizer | Dog, Cat, Organic Waste Remover (1 Gallon)

Why we love it
  • Powerful stain and odor elimination.
  • Safe for kids and pets.
  • Trusted by professionals and homeowners.
Main Highlights
  • Powerful Enzymatic Action –Breaks down stains and odors at the source - from pet accidents to everyday messes. Keep your home fresh, clean, and worry-free.
  • Eliminates Odors in Seconds –Neutralizes dog, cat, and human urine smells from carpets, floors, drains, and more. Because life’s too short for lingering odors.
  • Multi-Surface Safe & Family-Friendly – Gentle on carpets, hardwood, tile, upholstery, and more — tough on messes, safe for pets and kids. Clean with confidence.
  • Perfect for Pet Accidents & Beyond –Tackles stains, urine, vomit, and more — from litter boxes to kennels to everyday spills. Freshness where you need it most.
  • Commercial Strength. Home Safe. –Trusted by homeowners, vets, and cleaners alike — biodegradable, non-toxic, and ready for the toughest jobs, big or small.
9.2
Superb
Amazon Logo
8
9.1
Superb
Nature's Miracle Urine Destroyer, Cat Urine Enzyme Cleaner, Pour, 128 fl oz
Nature's Miracle

Nature's Miracle Urine Destroyer, Cat Urine Enzyme Cleaner, Pour, 128 fl oz

Why we love it
  • Effectively eliminates stubborn stains.
  • Leaves a refreshing scent.
  • Versatile for various surfaces.
Main Highlights
  • Targeted urine destroyer
  • Tough on strong pet urine and the Yellow, sticky residue
  • Freshens with a light fresh scent
  • For use on carpets, hard floors, furniture, fabrics and more
9.1
Superb
Amazon Logo
9
8.9
Excellent
Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz
Rocco & Roxie Supply Co.

Rocco & Roxie Supply Co. Stain & Strong Odor Eliminator, Enzyme Cleaner, Pet Odor Eliminator for Home - Carpet Stain Remover for Cats & Dog Pee - Urine Destroyer - Carpet Cleaner Spray Clear, 32 Fl Oz

Why we love it
  • Certified safe for kids and pets.
  • Eliminates tough stains and odors.
  • Works on all surfaces everywhere.
Main Highlights
  • Certified Gentle & Safe Pet Carpet Cleaner Solution: Chlorine free, color safe, no hazardous propellants or residue; safe to use around pets and children; certified safe for all carpets with a Seal of Approval by the Carpet and Rug Institute (CRI)
  • Pet Enzyme Carpet Cleaner for Stains, Odors, Residue: If it's gross, it's gone; the stain and the stink; from stinky yellow pet urine, feces to vomit or other organic spills, Rocco & Roxie professional strength stain & odor eliminator tackles it all
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Cat & Dog Urine Enzyme Cleaner for Every Surface, Every Time: For use on carpets, floors, furniture, clothing, litter boxes, kennels, carriers, all pet living and sleeping areas—anywhere stains happen enzyme cleaner for dog urine
  • Buy With Confidence: You want the best for your best friend; we do, too; if you are not satisfied with the performance of this Rocco & Roxie stain & odor eliminator, contact us; we are determined to make it rightx
8.9
Excellent
Amazon Logo
10
8.9
Excellent
Nature's Miracle Stain and Odor Remover Cat, Odor Control Formula, Pour
Nature's Miracle

Nature's Miracle Stain and Odor Remover Cat, Odor Control Formula, Pour

Why we love it
  • Tough on tough pet stains.
  • Multi-surface application versatility.
  • Safe for pets and family.
Main Highlights
  • TOUGH ON STAINS AND ODORS: This stain and odor remover is tough on cat urine, feces, vomit, drool and other organic stains and odors.
  • MULTI-SURFACE USE: When used and stored as directed, this product is safe for use on carpets, hard floors, furniture, fabrics and more.
  • SAFE FOR PETS AND HOME: We’ve been loved by pet parents for over 35 years, so we know the importance of having effective stain and odor remover that, when used and stored as directed, is safe to use around pets.
  • CITRUS SCENT: In addition to removing stains and odors, this product freshens with a light citrus scent.
  • TRUSTED BRAND: From the maker of Nature’s Miracle products, the pet stain and odor removing brand you trust… because it works.
8.9
Excellent
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Related Deals You Might Like for Cat Urine Enzyme Cleaner

📊We scanned 1679 products
🔍
We reviewed the most relevant Cat Urine Enzyme Cleaner offers across Amazon and leading retailers, covering major brands and models. Our shortlist features trusted names like ACTIVE, Bioda, Nature's Miracle, Biokleen, Rocco & Roxie Supply Co., Black Diamond Stoneworks, known for dependable quality and smart design.
⭐
To determine today's best Cat Urine Enzyme Cleaner, we analyzed 8396 real customer and expert reviews, focusing on satisfaction, real-world performance and long-term reliability. We also weigh each review's relevance, authenticity and freshness for a fair comparison.

Here's what we found:

🏆 #1
Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil

Our overall winner is Pet Odor and Stain Eliminator - 32 oz ACTIVE Enzyme Cleaner for Dog & Cat Urine, Stain Remover Spray for Carpet, Upholstery, Hardwood, Spot Cleaning, Deodorizer for Dogs Cats Pets - Natural Citrus Oil by ACTIVE. It stands out for the right balance of quality, performance and value.

✨ What sets it apart:
✓Completely eliminates odors and stains.
✓Powerful enzymatic cleaning formula.
✓Safe for pets and children.
💎 Best Value
Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon

The best value for most shoppers is Bioda Multi-Purpose Probiotic Enzyme Cleaner and Deodorizer | Professional Strength | Trash Can Deodorizer, Pet Stains and Odors, Drains, Floors, Bathrooms, Toilets | Made in USA | 1 Gallon by Bioda, with consistently high satisfaction across expert and customer reviews.

💰 Best Deal
Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces

The strongest deal right now for Cat Urine Enzyme Cleaner is Biokleen Bac-Out Enzyme Cleaner and Stain & Odor Remover for Pet Stains, Laundry, Diapers, Wine, Carpets, & More, Eco-Friendly, Non-Toxic, Lime Scent, 128 Ounces at Biokleen, currently at 22% off.

🔄Our Cat Urine Enzyme Cleaner ranking is updated regularly to reflect new releases and price changes—check back for the latest picks and deals.